Publication of the FDA Final Rule has stimulated a number of claims for water and feed additives that can inhibit or assist in suppressing SE infection.

One compound which has been promoted comprises a chelated copper solution intended to decontamination contaminated green produce and to suppress algae in irrigation water.

Compounds including organic acids with proven efficacy against paratyphoid serotypes of salmonella in feed will have little impact on the incidence of SE since the infection is not food-borne. The epidemiology of this infection suggests that a comprehensive approach to prevention is required incorporating adherence to a program such as the PEQAP. This would require placing SE-free chicks, certified in accordance with the NPIP, administration of both live attenuated mutant and inactivated oil emulsion vaccines, suppressing rodent infestation and implementing a program of monitoring the environment of flocks using manure swabs.


Probiotics and prebiotics or their combination could be beneficial in modifying intestinal flora to inhibit colonization of the intestinal tract with salmonella including SE and would be especially useful during the brooding period in conjunction with vaccination and effective inter-flock decontamination.

Epidemiologic studies have shown that SE is not generally associated with infection via the water or feed routes. Accordingly, claims by manufacturers of commercial additives to offer a “quick fix” for SE are without scientific foundation.