Responsible antimicrobial use, proper animal care and stakeholder collaboration are key components of the ‘One Health’ approach as all work to minimize the use of antibiotics in food animals and the sector’s contribution to the potential development of antimicrobial resistance. The third OIE report on the global use of antimicrobials is a significant contribution to ensure more accurate information is available so informed decisions can be made to advance evidence-based antimicrobial stewardship practices globally.