Finding the right necrotic enteritis (NE) and coccidiosis combination just got easier. Elanco Animal Health announces that Inteprity a first-in-class, animal-use- only, in-feed antibiotic, is now approved for combination use with Maxiban starting in the feed any time between 0 and 18 days of age and fed continuously for 21 days. Additionally, this combination approval allows Maxiban to be used with zero-day withdrawal.
This label change helps poultry producers give broilers the gut health protection they need and consumers the peace of mind they want.
More flexibility, target peak challenges
Expanding the Inteprity start window in combination with the Maxiban ionophore to 18 days gives poultry producers more flexibility in the fight against coccidiosis and NE. Inteprity can also be used in combination with Monteban, Coban and Bio-Cox when implemented between Day 0 and Day 18 of age and fed continuously for 21 days.
“Peak necrotic enteritis challenges begin at or around 21 days of age, the new Inteprity label means poultry producers can target the peak NE challenge by adding Inteprity later in the starter feed,” said Bob Evans, D.V.M., Elanco technical consultant. “This means poultry producers can simplify feeding logistics and have more flexibility when creating feed programs to address necrotic enteritis challenges.”
In field trials, Inteprity (avilamycin) reduced mortality due to necrotic enteritis between 76 to 93 percent versus the control group.1-3
Maxiban provides dual-action mechanism to control Cocci
Poultry producers can combine the first-in-class protection of Inteprity to control NE with the strength of Maxiban. Maxiban combines an ionophore and a chemical to pose a dual threat to coccidia. The low levels of both nicarbazin and narasin create a complex mode of action that minimizes the genetic pressure on coccidia populations, resulting in long-term efficacy with minimal risk of resistance development with zero-day withdrawal. 5,6
Diseases like coccidiosis and NE remain a serious and constant threat to the health and welfare of poultry flocks. Additionally, the incidence of NE in poultry houses is on the rise, with daily mortality rates as high as 1 percent.4,5 The unseen, profit-robbing, subclinical symptoms are even more common than clinical outbreaks — reducing weight gain and feed efficiency.5,6 NE can cost up to $0.05 per bird in the U.S.7 — or $50,000 per every 1 million birds. With producers facing continuous threat of disease, Elanco is dedicated to providing the latest innovations in poultry health and helping producers maximize the use of in-feed products.
“Research shows that when fed in starter or starter-grower feeds, animal-use only programs using Inteprity provide significantly better feed conversion ratios than shared-class programs,” said Evans.
Inteprity Field Trial8
An integrated broiler producer conducted a field trial comparing the effects of Inteprity, BMD® and Stafac® on mortality caused by necrotic enteritis in 21 million broilers during the summer and fall growing periods.
As a result of using Inteprity for NE at a rate of 22.7 g/ton in the starter feed on days 0-21, the broilers in the field trial also had improved weight gain and adjusted feed conversion compared to feeding BMD or Stafac during the same period.
Visit Elanco.us/Inteprity for more information.
1Elanco Animal Health. Data on file.
2Elanco Animal Health. Data on file.
3Elanco Animal Health. Data on file.
4Williams R. Intercurrent coccidiosis and necrotic enteritis of chickens: rational, integrated disease management by maintenance of gut integrity. Avian Pathol. 2005;34(3):159-180.
5Van Immerseel F. Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol. 2009;17(1):32-36.
6Timbermont L. Necrotic enteritis in broilers: An updated review on the pathogenesis. Avian Pathol. 2011;40(4):341-347.
7McDevitt R, Brooker J et al. Necrotic enteritis: a continuing challenge for the poultry industry. World’s Poultry Science Journal. 2006;62:221-247.
8Elanco Animal Health. Data on file.
The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions.
Coban directions for use:
As an aid in the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati and E. maxima in broiler chickens:
• Feed Coban 90-110 g/ton
• Feed continuously as the sole ration
• Requires a zero-day withdrawal (when fed according to the label)
For the prevention of coccidiosis in turkeys caused by Eimeria adenoeides, E. meleagrimitis and E. gallopavonis:
• Feed Coban 54-90 g/ton to turkeys
• Feed continuously as the sole ration
• Requires a zero-day withdrawal (when fed according to the label)
IMPORTANT SAFETY INFORMATION
WARNING: Do not feed to laying chickens. Do not feed to chickens over 16 weeks of age.
CAUTION: Do not allow horses, other equines, mature turkeys, or guinea fowl access to feed containing monensin. Ingestion of monensin by horses and guinea fowl has been fatal. Some strains of turkey coccidia may be monensin tolerant or resistant. Monensin may interfere with development of immunity to turkey coccidiosis. In the absence of coccidiosis in broiler chickens, the use of monensin with no withdrawal period may limit feed intake resulting in reduced weight gain. Not for replacement chickens intended to become broiler breeding chickens.
Inteprity directions for use:
For the prevention of mortality caused by necrotic enteritis associated with Clostridium perfringens in broiler chickens:
• Avilamycin is to be fed at 13.6 to 40.9 grams per ton of Type C medicated feed (15 to 45 ppm) as the sole ration for 21 consecutive days.
• Feed to chickens that are at risk of developing, but not yet showing clinical signs of, necrotic enteritis associated with Clostridium perfringens
IMPORTANT SAFETY INFORMATION
CAUTION: Federal law restricts medicated feed containing this veterinary feed directive (VFD) drug to use by or on the order of a licensed veterinarian.
• To assure responsible antimicrobial drug use in broiler chickens, treatment administration must begin on or before 18 days of age.
• The safety of avilamycin has not been established in chickens intended for breeding purposes.
• Avilamycin has not been demonstrated to be effective in broiler chickens showing clinical signs of
necrotic enteritis prior to the start of medication.
• The veterinary feed directive (VFD) expiration date must not exceed 90 days from the date of
issuance. VFDs for avilamycin shall not be refilled.
Maxiban directions for use:
For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati and E. maxima in broiler chickens:
• Feed Maxiban at 54-90 g/ton.
• Feed continuously as the sole ration
• Requires a zero-day withdrawal (when fed according to the label), some combination use requires
5–day withdrawal.
CAUTION: Nicarbazin medicated broilers may show reduced heat tolerance if exposed to high temperature and high humidity. Provide adequate drinking water and ventilation.
Do not allow adult turkeys, horses, or other equines access to formulations containing narasin. Ingestion of narasin by these species has been fatal. Do not feed to laying hens.
Monteban directions for use:
For the prevention of coccidiosis caused by Eimeria necatrix, E. tenella, E. acervulina, E. brunetti, E. mivati and E. maxima in broiler chickens:
• Feed Monteban at: 54–90 g/ton
• Feed continuously as the sole ration
• Requires a zero-day withdrawal (when fed according to the label)
CAUTION: Do not allow adult turkeys, horses or other equines access to narasin formulations. Ingestion of narasin by these species has been fatal.
